Biomimetic and bioinspired nano‐platforms for cancer vaccine development

نویسندگان

چکیده

The advent of immunotherapy has revolutionized the treating modalities cancer. Cancer vaccine, aiming to harness host immune system induce a tumor-specific killing effect, holds great promises for its broad patient coverage, high safety, and combination potentials. Despite promising, clinical translation cancer vaccines faces obstacles including lack potency, limited options tumor antigens adjuvants, immunosuppressive microenvironment. Biomimetic bioinspired nanotechnology provides new impetus designing concepts vaccines. Through mimicking stealth coating, pathogen recognition pattern, tissue tropism pathogen, other irreplaceable properties from nature, biomimetic could gain functions such as longstanding, targeting, self-adjuvanting, on-demand cargo release. specific behavior endogenous molecules each type living entity (cell or microorganism) offer unique features address needs immunotherapy. In this review, strategies inspired by eukaryotic cells, bacteria, viruses will be overviewed advancing vaccine development. Our insights into future development shared at end expediting translation.

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ژورنال

عنوان ژورنال: Exploration

سال: 2023

ISSN: ['2766-8509', '2766-2098']

DOI: https://doi.org/10.1002/exp.20210263